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SIRNA Sigma

MISSION® siRNA Product Offerings

Custom and Predesigned siRNA

Synonym: Custom siRNA, High-throughput siRNA, Predesigned siRNA, siRNA pools, siRNA

Predesigned siRNA

Extensive collection of human, mouse and rat siRNA. Multiple sequences are available for every gene, with rankings to indicate performance.


  • Scale: 10, 25, 50, and 250 nmol
  • Purification: Desalt or HPLC
  • Sequence Length: 21 bases
  • Modifications: Not available for this item
  • Quality Control: Individual strands are analyzed by mass spectrometry. Depending on manufacturing site, PAGE may be used to assess siRNA duplexes. siRNA quantity is systematically validated by UV absorbance at 260 nm.
  • Format: Supplied dry

Custom siRNA

Custom siRNA sequences with a wide range of modifications, purifications and quantities to tailor your unique sequence.


  • Scale: 10, 25, 50, and 250 nmol
  • Purification: Desalt or HPLC
  • Sequence Lengths: 19 - 27 bases
  • Modifications: Comprehensive offering of modifications and dyes (2'-O-Methyl, Amine, Cyanine dyes, Fluorescein, 6-FAM, Biotin, Phosphate, Thiol, Abasic, Phosphorothioate linkages, 2'-Fluoro).
  • Quality Control: Individual strands are analyzed by mass spectrometry. Depending on manufacturing site, PAGE may be used to assess siRNA duplexes. siRNA quantity is systematically validated by UV absorbance at 260 nm.
  • For additional purifications, sequence length or modifications,
    email sirnarequest@sial.com
  • Custom siRNA sequence design available for a variety of species,
    Learn more

Fast siRNA

Expedite your siRNA order! Orders are prioritized in the production process with a turn-around-time of only 3 days.


  • FAST siRNA is delivered in solution at concentrations of 50 µM (2 OD) or 100 µM (5 OD).
  • US orders must be received by 11 AM CST. European orders must be received by 11 AM CET.
  • Easy to use Fast siRNA ordering tool.

siRNA Pools

siRNA pools are available for pre-designed or custom siRNA sequences. Each pool provides four duplexes at 5 nmol per duplex (20 nmol total/pool). Each siRNA duplex is also provided at 5 nmol in individual tubes.


  • Scale: 2 OD /10 nmol per duplex
  • Purification: Desalt or HPLC
  • Sequence Length: 21 bases
  • Modifications: Comprehensive offering of modifications and dyes (2'-O-Methyl, Amine, Cyanine dyes, Fluorescein, 6-FAM, Biotin, Phosphate, Thiol, Abasic, Phosphorothioate linkages, 2'-Fluoro).
  • Quality Control: Individual strands are analyzed by mass spectrometry. Depending on manufacturing site, PAGE may be used to assess siRNA duplexes. siRNA quantity is systematically validated by UV absorbance at 260 nm.
  • Format: Supplied dry

iScale Oligos™ - siRNA

siRNA provided in larger quantities for in vivo, high throughput or diagnostic projects.


  • Amount: 1 – 10 mg, 50 mg – 1 g
  • Purification: Desalt, RPC (cartridge purified), HPLC and In vivo quality
  • Sequence Length: 19 - 45 bases
  • Comprehensive offering of modifications including dyes, amines, biotin, linkers, etc.
  • Quality Control: Individual strands are analyzed by mass spectrometry. Depending on manufacturing site, PAGE may be used to assess siRNA duplexes. siRNA quantity is systematically validated by UV absorbance at 260 nm.
  • In vivo option includes HPLC-purification to >/= 90%, desalt, filtration and endotoxin testing.
  • To inquire for availability of additional quantities, modifications or purifications, email sirnarequest@sial.com

siRNA Controls

Universal Negative Controls.


  • Two distinct siRNA control sequences designed for use in Human, Mouse, or Rat cells.
  • Validated with Agilent 40K human gene arrays to ensure no significant nonspecific gene interactions.
  • Functionally validated to show no immune response via qRT PCR.
  • Learn more

Positive Control siRNA.


  • Validated human and rat positive controls to simplify transfection optimization.
  • Learn more

siRNA Nano scale

Small scale siRNA screening option for human kinase or phosphatase genes. Available as individuals or a gene family set.


  • Scale: 0.25 nmol
  • Purification: Desalt
  • Sequence Length: 21 bases
  • Modification: Not available for this item.
  • Quality Control: Individual strands are analyzed by mass spectrometry. Depending on manufacturing site, PAGE may be used to assess siRNA duplexes. siRNA quantity is systematically validated by UV absorbance at 260 nm.
  • Format: Supplied dry

RNA Oligos

  • Scale: 0.05, 0.2, 1.0 µmol
  • Purification: Desalt, HPLC and PAGE
  • Sequence Length: 7 - 45 bases
  • Modification options available
  • Quality Control: 100% mass spectrometry
  • Format: Supplied dry
  • Learn more about RNA Oligos

MISSION® siRNA Transfection Reagent

  • Superior gene silencing in a wide variety of eukaryotic cell types
  • For use with siRNA, esiRNA, miRNA mimics and Synthetic miRNA inhibitors
  • Learn more

N-TER™ Nanoparticle siRNA Transfection System

  • Peptide transfection reagent for use in difficult to transfect cells.
  • Learn more

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?