When downstream quality matters, make sure your upstream tools are the best. The last steps of preparing a protein sample for downstream analyses, such as activity assays or structural studies, involve ensuring that the protein is in its native, soluble form, dissolved in the buffer of choice, and at an appropriate concentration. Our membrane-based technologies, including tangential flow filtration (TFF)-based separation, enable fast, easy concentration, desalting and buffer exchange.

  • Importance of TFF for concentration
  • Centrifuge and Rotor Recommendations

How to Concentrate Your Protein Samples

For reproducible protein assay results, you need to purify your protein of interest without denaturing it, losing its enzymatic activity or binding functions. Concentrate it without compromising yield, even if it’s labile or low in abundance. We offer several fast, gentle, membrane-based options for concentrating and fractionating your protein.

  • Amicon® Ultra centrifugal filters for protein concentration
  • High-throughput protein concentration and desalting
  • Clarification with Pellicon® tangential flow microfiltration
  • Pellicon® tangential flow ultrafiltration

Nucleic Acid Concentration

Given the ever-increasing complexity of your genetic manipulations, purification and concentration of nucleic acids shouldn’t be a rate-limiting step. With our membrane-based technologies, you can eliminate time-consuming precipitation steps for clean, high yields of DNA or RNA. For higher throughput molecular biology, use our MultiScreen® plate-based tools that allow you to process up to 384 samples at once, either manually or using automation.

  • High-throughput PCR purification
  • Plasmid and BAC preparation
  • DNA extraction from agarose gels
  • Purification with MultiScreen® plates

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