Anti-biofilm efficacy of nitric oxide-releasing silica nanoparticles.

Biomaterials (2009-02-24)
Evan M Hetrick, Jae Ho Shin, Heather S Paul, Mark H Schoenfisch

The ability of nitric oxide (NO)-releasing silica nanoparticles to kill biofilm-based microbial cells is reported. Biofilms of Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, and Candida albicans were formed in vitro and exposed to NO-releasing silica nanoparticles. Replicative viability experiments revealed that >or= 99% of cells from each type of biofilm were killed via NO release, with the greatest efficacy (>or= 99.999% killing) against gram-negative P. aeruginosa and E. coli biofilms. Cytotoxicity testing demonstrated that the highest dose of NO-releasing silica nanoparticles inhibited fibroblast proliferation to a lesser extent than clinical concentrations of currently administered antiseptics (e.g., chlorhexidine) with proven wound-healing benefits. This study demonstrates the promise of employing nanoparticles for delivering an antimicrobial agent to microbial biofilms.

Product Number
Product Description

Tetraethyl orthosilicate, reagent grade, 98%
Tetraethyl orthosilicate, ≥99.0% (GC)
Tetraethyl orthosilicate, 99.999% trace metals basis
Tetraethyl orthosilicate, packaged for use in deposition systems

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