• Home
  • Search Results
  • Janus nanocarrier powered by bi-enzymatic cascade system for smart delivery.

Janus nanocarrier powered by bi-enzymatic cascade system for smart delivery.

Journal of materials chemistry. B (2019-08-01)
Sandra Jimenez-Falcao, Natalia Joga, Alba García-Fernández, Antoni Llopis Lorente, Daniel Torres, Beatriz de Luis, Félix Sancenón, Paloma Martínez-Ruiz, Ramón Martínez-Máñez, Reynaldo Villalonga
ABSTRACT

We report herein the assembly of an integrated nanodevice with bi-enzymatic cascade control for on-command cargo release. This nanocarrier is based on Au-mesoporous silica Janus nanoparticles capped at the mesoporous face with benzimidazole/β-cyclodextrin-glucose oxidase pH-sensitive gate-like ensembles and functionalized with invertase on the gold face. The rationale for this delivery mechanism is based on the invertase-mediated hydrolysis of sucrose yielding glucose, which is further transformed into gluconic acid by glucose oxidase causing the disruption of the pH-sensitive supramolecular gates at the Janus nanoparticles. This enzyme-powered device was successfully employed in the autonomous and on-demand delivery of doxorubicin in HeLa cancer cells.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
(3-Iodopropyl)trimethoxysilane, ≥95.0% (GC)

Social Media

LinkedIn icon
Twitter icon
Facebook Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.