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Mitochondrial Stress and ROS
Oxidative stress is mediated, in part, by reactive oxygen species produced by multiple cellular processes and controlled by cellular antioxidant mechanisms such as enzymatic scavengers or antioxidant modulators. Free radicals, such as reactive oxygen species, cause cellular damage via cellular.
P2 Receptors: P2Y G-Protein Family
P2 Receptors: P2Y G-Protein Family
Vasoactive Intestinal Peptide Receptors
Sigma-Aldrich offers many products related to vasoactive intestinal peptide receptors for your research needs.
Lysophospholipid Receptors
Sigma-Aldrich offers many products related to lysophospholipid receptors for your research needs.
Glutamate Receptors (Ion Channel Family)
We offers many products related to ion channel family glutamate receptors for your research needs.
Calcitonin Gene-Related Peptides
Sigma-Aldrich offers many products related to calcitonin gene-related peptides for your research needs.
Nucleotide Synthesis in Cancer Cells
Neoplastic cells are highly dependent on the de novo synthesis of nucleotides to maintain sufficient pools to support DNA replication and the production of RNA.
InsP3/Ryanodine Receptors
Ryanodine and InsP3 receptors share both structural and functional characteristics. Both receptor families are made up of subunits that are among the largest of known proteins and for each the functional channel comprises a tetramer in which six membrane-spanning helices...
Omega-3 Fatty Acids and Heart Disease
The potential for the prevention and treatment of cardiovascular disease through increased dietary intake of omega-3 (w-3) fish oils is not a recent scientific discovery.
Lipoprotein Function
Sigma-Aldrich's online Enzyme Explorer Key Resource: Lipoprotein Function includes prducts, overview, classification, , properties and function.
Fatty Acid Synthesis and Metabolism in Cancer Cells
Information on fatty acid synthesis and metabolism in cancer cells. Learn how proliferatively active cells require fatty acids for functions such as membrane generation, protein modification, and bioenergetic requirements. These fatty acids are derived either from dietary sources or are...
P2 Receptors: P2X Ion Channel Family
We offer many products related to P2X ion channel family receptors for your research needs.
Folic Acid Metabolism: A Role in Cancer's Cause and Cure
This article reviews some of our newest and most innovative technologies and their specific applications toward cancer research. It describes how complex the disease of cancer is, and how difficult it is to identify one topic that is completely...
Glutamine Metabolism is Dysregulated in Many Cancer Cells
Sigma-Aldrich presents an article about how proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metabolites away from mitochondrial oxidative...
Vasopressin and Oxytocin Receptors
Sigma-Aldrich offers many products related to vasopressin and oxytocin receptors for your research needs.
Dietary Antioxidants
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
GABAB Receptors
Sigma-Aldrich offers many products related to GABAB receptors for your research needs.
Cannabinoid Receptors
Sigma-Aldrich offers many products related to cannabinoid receptors for your research needs.
β-Adrenoceptors
β-Adrenoceptors are activated either by norepinephrine or epinephrine. Learn more about the role of β-adrenoceptors in protein expression, cell signaling, and metabolism research.
Dopamine Receptors
Sigma-Aldrich offers many products related to dopamine receptors for your research needs.
α2-Adrenoceptors
α2-Adrenoceptors
Glutamate/GABA Synthesis and Metabolism
Glutamine is a common precursor for the biosynthesis of both glutamate and GABA. Glutamine can be transported in and out of neurons and astrocytes utilizing different glutamine carriers. The neurotransmitter glutamate can be synthesized from glutamine by the action of...
GABAC Receptors
Sigma-Aldrich offers many products related to GABAC receptors for your research needs.
Histamine Receptors
We offers many products related to histamine receptors for your research needs.
Adenylyl Cyclase
Adenylyl cyclases occur throughout the animal kingdom and play diverse roles in cell regulation. In bacteria, the enzyme may be regulated in response to nutrients or it may constitute a toxic factor in mammals, as with adenylyl cyclases of B....
Cholesterol Transport
Since cholesterol is a water-insoluble molecule it must be packaged for transport within the plasma. The particles that package cholesterol, cholesteryl esters, and triglycerides for transport, are called lipoproteins.
CypExpress™ – A Human Cytochrome P450 Catalytic System
Each CypExpress product is comprised of a specific, unmodified recombinant human CYP, P450 oxidoreductase cofactors, and antioxidants encapsulated in a semipermeable shell – allowing rapid diffusion of substrates and products.
¹³ C MRS to Probe Brain Metabolism Using Hyperpolarized Pyruvic Acid
We present an article about the hyperpolarization of 13C labeled metabolites, especially pyruvic acid, using dynamic nuclear polarization (DNP) that allows real-time magnetic resonance spectroscopy.
Thrombin Factor IIa
Thrombin Factor IIa is an endolytic serine protease that selectively cleaves the Arg--Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.
Glycine Receptors
The amino acid glycine is a major inhibitory neurotransmitter in the vertebrate CNS. Glycinergic synapses are particularly abundant in spinal cord and brain stem, but are also found in higher brain regions including the hippocampus. The inhibitory actions of glycine...

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