Applications
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Showing 1-30 of 41 results
DNA Damage and Repair
DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
Studies of Dimerization and Activation of Receptors in the EGFR-Family Using Duolink® Assays
Our aim was to investigate the dimerization and activation pattern of two receptors, EGFR (ErbB1) and HER2 (ErbB2), in the EGFR-family using breast cancer cell lines and selected colon tissues as model systems.
Vitamin D and Prevention of Human Disease
Vitamin D2 (ergocalciferol) is naturally synthesized from ergosterol by invertebrates, fungi, and plants in response to ultraviolet B irradiation, while vitamin D3 synthesis (cholecalciferol) is uniquely initiated in the skin of vertebrates. During sun exposure, ultraviolet B photons are absorbed...
Angiostatin and Endostatin: Key Players in a Dual Threat Approach to Cancer Treatment
Anticancer drugs development - natural and synthetic angiogenesis inhibitors.
Ginseng (Panax quinquefolius) Augments Doxorubicin-Induced Inhibition of Human Breast Cancer Cell Proliferation and Tumor Growth: Mechanisms of Action
Ginseng root extract inhibits the proliferation of human cancer cells in vitro, including those that represent many common cancers, such as breast cancer. Ginseng extracts contain over 20 different ginsenosides, saponin glycosides that are biologically active constituents of ginseng. Several...
Autophagy Mitophagy in Tumor Cell Survival Death
Autophagy is a highly regulated process that is involved in cell growth, development, and death. In autophagy cells destroy their own cytoplasmic components in a very systematic manner and recycle them.
Autophagy in Cancer Promotes Therapeutic Resistance
We presents an article on Autophagy in Cancer Promotes Therapeutic Resistance
Oncogenes and Tumor Suppressors Reprogram Metabolism
We present an article about how proliferating cells require the biosynthesis of structural components for biomass production and for genomic replication.
TokeOni: Properties and Applications
Bioluminescence imaging (BLI) systems allows for high-sensitive and noninvasive monitoring of cell proliferation, activity of signaling pathways and protein-protein interactions in living tissues.
Overview of Cancer Biology
We deliver the broadest selection available of carcinogenic and chemopreventive biochemicals, as well as research reagents and kits for apoptosis, angiogenesis, biomarker identification, metabolomics, and functional genomics.
Epigenetic Mechanisms in Cancer Pathogenesis
This page reviews some of our newest and most innovative technologies and their specific applications toward cancer research. One is reminded of how complex the disease of cancer is, and how difficult it is to identify one topic that is...
Folic Acid Metabolism in Cancer
This issue of Biofiles reviews some of our newest and most innovative technologies and their specific applications toward cancer research. In preparing this issue of Biofiles, one is reminded how complex the disease of cancer is, and how difficult it...
Immunohistochemistry: Current Applications in Breast Cancer
Immunohistochemistry (IHC) is used to characterize intracellular proteins or various cell surfaces in all tissues. Individual markers or more often panels of various marker proteins can be used to characterize various tumor subtypes, confirm tissue of origin, distinguish metastatic from...
Co-culture of Tumor and Stromal Cells in TrueGel3D™ Hydrogels
TrueGel3D™ synthetic hydrogel can be used to study co-culture of tumor and stromal cells.
Cancer Stem Cells: Targets for Cancer Therapy
Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
NF-κB and Inflammation
NF-κB and Inflammation
Epidermal growth factor receptor (EGFR) signaling
Read review on EGF/EGFR signaling (epidermal growth factor receptor) and find links to related products at sigmaaldrich.com
Immunohistochemistry Applications in Gastrointestinal Cancer
Colorectal cancer is the third most common cancer in both men and women. An estimated 136,000 cases of colorectal cancer are expected to occur in 2016.
Dynamic Live Cell Imaging of Caspase Mediated Apoptosis and Cellular Hypoxia in Lymphocytes and Cancer Cells Using the CellASIC® ONIX2 Microfluidic Platform
Application note on how the CellASIC® ONIX2 microfluidic system can be used to analyze caspase-3 mediated apoptosis/cell death and cellular hypoxia in live immune and cancer cell lines.
Epigenetics Overview
Epigenetics is a term coined to describe changes that are not mutation based but can still be passed on from generation to generation. Genes that are activated or repressed without any change in DNA sequence are epigenetically controlled. Epigenetic modifications...
Application of Corning® CellSTACK®-5 Chamber with the Corning CellBIND® Surface to Simplify and Enhance Mass-Production of Recombinant Proteins
Discover how the Corning CELLSTACK-5 Chamber is used to simply and enhance the mass production of recombinant proteins.
Primary Cell Culture Basics
What are primary cells? A comprehensive overview of animal and human primary cell lines and media and how they are used in biomedical cell culture applications. Primary cultures are less homogeneous relative to cell lines.
Hypoxia Detection Assays
Hypoxia detection assays to measure oxygen levels in both live and fixed cells and tissues.
Fibroblast Growth Factor Family (FGF)
Fibroblast growth factors in cell culture and various growth factors for your research
Applications of Cytokines and Growth Factors in Cancer Research
Applications of Cytokines and Growth Factors in Cancer Research
Cancer Stem Cell Proliferation in Human Prostate and Breast Cancer Cell Lines Utilizing a New Defined Serum-Free 3D Spheroid Media
Serum-free defined cancer stem cell media used to grow and expand cancer cells in 3D tumorsphere aggregates.
Cell Migration & Invasion Assays
Metastasis is the cumulative result of multiple changes in tumor cells. Explore tumor metastasis employing various cell migration and invasion assays like Boyden chamber assay, Millicell® µ-Migration Assay and in vitro scratch assay.
Angiogenesis Assays
Cell based angiogenesis assays to analyze new blood vessel formation for applications of cancer research, tissue regeneration and vascular biology.
Long-Term Live Cell Tracking of Cancer and Stem Cells Using a Biocompatible Fluorescent Nanoparticle Based Upon Aggregation Induced Emission (AIE Dot) Nanotechnology
Biocompatible organic fluorescent nanoparticles (AIE Dots) that can be used to label cells and vasculature for long-term live cell tracking and tracing experiments.
Cell Tracking with Lipophilic Membrane Dyes
Optimal staining is a key component for studying tumorigenesis and progression. Learn useful tips and techniques for dye applications, including examples from recent studies.

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