Showing 1-30 of 389 results for "78-10-4"
So Ri Kim et al.
The Journal of allergy and clinical immunology, 132(6), 1397-1408 (2013-10-29)
Despite many studies on endoplasmic reticulum (ER) stress in patients with various inflammatory diseases, there is scarce information on ER stress in patients with bronchial asthma. In this study we aimed to elucidate the role of ER stress in the...
Yeshwant Singh et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(8), 731-740 (2015-03-24)
1. The study aimed to investigate the influences on the pharmacokinetics (PK) of an anti-malarial drug 97/78 in rats pretreated with orally administered rifampicin and bacterial endotoxin lipopolysaccharide (LPS). 2. In-situ intestinal absorption studies were conducted on rats pretreated with rifampicin and...
M Xia et al.
Journal of immunology (Baltimore, Md. : 1950), 157(3), 1132-1138 (1996-08-01)
The major immunoregulatory effects of vasoactive intestinal peptide (VIP) are mediated by structurally distinct types I (VIPR1) and II (VIPR2) G protein-associated receptors on some T cells, B cells, and macrophages. Identification of the separate immunologic activities of each type...
Helen J Renaud et al.
Toxicological sciences : an official journal of the Society of Toxicology, 124(2), 261-277 (2011-09-17)
Cytochrome P450 (Cyp) enzymes from the first four families (Cyp1-4) play a major role in metabolizing xenobiotics, affecting drug pharmacokinetics and chemical-induced toxicity. Due to cloning of the mouse genome, many novel Cyp isoforms have been identified, but their tissue...
Kenji Tsushima et al.
Respirology (Carlton, Vic.), 13(4), 546-552 (2008-04-16)
Chronic inhalation of spores may cause respiratory symptoms such as productive cough and sputum. The purpose of this study was to determine the clinical pathophysiology of airway inflammation caused by bunashimeji spores and to investigate whether the spores have direct...
Martina Vasakova et al.
Respiratory medicine, 103(5), 773-779 (2009-01-02)
The aim of our study is to investigate correlations of T(H)1/T(H)2 cytokine gene polymorphisms and bronchoalveolar lavage fluid (BALF) cytokine values in interstitial lung diseases (ILD). In 16 sarcoidosis, 7 idiopathic pulmonary fibrosis (IPF) and 8 hypersensitivity pneumonitis (HP) patients...
Meera Mahalingam et al.
The American Journal of dermatopathology, 32(8), 774-779 (2010-08-12)
The overlap in histopathologic features and immunoprofile of eccrine and apocrine neoplasms confounds basic issues relating to lineage of these entities. We evaluated expression of follicular stem-cell markers, cytokeratin (CK) 15 and nestin, in 78 benign and 23 malignant adnexal...
Carlos H Burgos et al.
Journal of the American Chemical Society, 127(22), 8044-8049 (2005-06-02)
The remarkable versatility and selectivity of the 10-(trimethylsilyl)-9-borabicyclo[3.3.2]decanes (10-TMS-9-BBDs) in the allyl- and crotylboration of representative aldehydes are reported. The new reagents are prepared through air-stable crystalline pseudoephedrine borinic ester complexes of the 10-TMS-9-BBDs (4), which are available in 63%...
X D Wang et al.
European journal of clinical investigation, 39(7), 607-617 (2009-06-24)
A majority of studies predicting the foetal RhD blood group in free foetal DNA from RhD-negative maternal plasma have been conducted in Caucasian populations, whereas limited data have been accumulated for Asian populations. In this study, we assessed the feasibility...
Abdalla E A Hassan et al.
Nucleosides, nucleotides & nucleic acids, 28(5), 642-656 (2010-02-26)
Metalation of 6-methyl-9-(tetrahydro-2H-pyran-2-yl)purine (10) with lithiating agents of varying basicities such as n-BuLi and LiHMDS in THF at -78 degrees C resulted in metalation at both of the 6-CH(3) moiety and the 8-CH position, irrespective of the molar equivalence of...
S Tayyab et al.
International journal of biological macromolecules, 26(2-3), 173-180 (1999-10-12)
In order to study the involvement of lysine residues of human serum albumin (HSA) in the binding of indomethacin, HSA was treated with different molar excess of acetic anhydride, succinic anhydride and O-methylisourea which resulted in differently modified preparations: 30%...
Martin Stanulla et al.
JAMA, 293(12), 1485-1489 (2005-03-24)
Early response to multiagent chemotherapy, including mercaptopurine, as measured by minimal residual disease is an important prognostic factor for children with acute lymphoblastic leukemia (ALL). Thiopurine methyltransferase (TPMT) is involved in the metabolism of mercaptopurine and subject to genetic polymorphism...
Yeshwant Singh et al.
Asian Pacific journal of tropical medicine, 8(8), 630-635 (2015-09-01)
To determine the potential drug-drug interactions between anti-malarial candidate 97/78 and anti-tubercular drug rifabutin in-vivo in rats followed by in-vitro investigation of the underlying mechanisms of drug interaction. Single oral dose study was conducted in male and female rats at...
Jenevaldo Barbosa Silva et al.
Ticks and tick-borne diseases, 6(4), 499-507 (2015-05-20)
Anaplasma marginale is the most prevalent tick-borne pathogen in cattle in tropical and subtropical regions of the world. Major Surface Protein 1a (MSP1a) has been found to be a stable genetic marker for identifying A. marginale isolates within geographical regions....
E R Parmee et al.
Bioorganic & medicinal chemistry letters, 10(20), 2283-2286 (2000-10-31)
Tetrahydroisoquinoline derivatives containing a 4-(hexylureido)benzenesulfonamide were examined as human beta3 adrenergic receptor (AR) agonists. Notably, 4,4-biphenyl derivative 9 was a 6 nM full agonist of the beta3 AR. Naphthyloxy compound 18 (beta3 EC50 = 78 nM) did not activate the...
P G Kramers et al.
Mutation research, 107(2), 187-201 (1983-02-01)
328 X-linked recessive lethal mutations induced in late spermatids by hycanthone methanesulfonate were tested for coverage by duplications that comprised, in total, about 24% of the euchromatic X chromosome; 78 lethals appeared to be covered. Crossover localization tests of a...
Kranti A Mapuskar et al.
Cancer research, 77(18), 5054-5067 (2017-08-03)
Elderly cancer patients treated with ionizing radiation (IR) or chemotherapy experience more frequent and greater normal tissue toxicity relative to younger patients. The current study demonstrates that exponentially growing fibroblasts from elderly (old) male donor subjects (70, 72, and 78...
X Wu et al.
Se pu = Chinese journal of chromatography, 16(6), 536-538 (2002-04-10)
A method for simultaneous determination of trace 4,4'-diaminobiphenyl, 4-nitrophenol and phenol in waste water by high performance liquid chromatography with spectrophotometric detection is reported. These components were separated on a Phenomenex Spherex C18 column with V(acetonitrile): V(ether): V(50 mmol.L-1 acetate)...
K J Soder et al.
Journal of dairy science, 96(4), 2551-2556 (2013-02-14)
A 4-unit continuous culture fermentor system was used to evaluate the effects of oilseed supplementation of an herbage-based diet on nutrient digestibility, fermentation profile, and bacterial nitrogen (N) synthesis. Treatments were randomly assigned to fermentors in a 4×4 Latin square...
Marcel Dautzenberg et al.
The Journal of physiology, 589(Pt 19), 4731-4744 (2011-08-10)
Nitric oxide (NO) blunts the myogenic response (MR) in renal blood flow (RBF) autoregulation. We sought to clarify the roles of NO synthase (NOS) isoforms, i.e. neuronal NOS (nNOS) from macula densa, endothelial NOS (eNOS) from the endothelium, and inducible...
Katarzyna Strawa et al.
Clinical endocrinology, 81(5), 769-774 (2014-05-13)
T-cell receptor rearrangement excision circles (TREC) are circular DNA molecules generated during T-cell maturation in the thymus. Recent studies suggested that a decreased TREC concentration in peripheral blood may be a general feature of autoimmunity. Our purpose was to assess...
X. Wang et al.
Plant physiology, 108(3), 1133-1139 (1995-07-01)
Regulation of the expression of the gene(s) coding for the 78-kD, biotin-containing subunit of [beta]-methylcrotonyl-coenzyme A carboxylase (MCCase) was investigated in different organs of tomato (Lycopersicon esculantus) plants. The specific activity of MCCase is highest in extracts from roots, followed...
Wen-Bin Yagn et al.
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 30(6), 728-731 (2009-02-03)
To investigate the expressions of prostate stem cell antigen (PSCA) and Claudin-4 in human pancreatic carcinoma and to discuss its role in the ontogenesis of pancreatic cancer. Pancreatic carcinoma tissue microarray was constructed, containing 100 cores of 10 normal adult...
Devi Rajan et al.
PloS one, 9(12), e114322-e114322 (2014-12-17)
Infections with human rhinovirus (HRV) are commonly associated with acute upper and lower respiratory tract disease and asthma exacerbations. The role that HRVs play in these diseases suggests it is important to understand host-specific or virus-specific factors that contribute to...
R W Neumar et al.
Journal of neurochemistry, 66(1), 421-424 (1996-01-01)
Proteolytic degradation of numerous calpain substrates, including cytoskeletal and regulatory proteins, has been observed during brain ischemia and reperfusion. In addition, calpain inhibitors have been shown to decrease degradation of these proteins and decrease postischemic neuronal death. Although these observations...
Resul Yilmaz et al.
Journal of paediatrics and child health, 45(11), 641-645 (2009-10-23)
Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterised by recurrent episodes of fever, polyserositis and rash. The aim of this study was to determine the most common mutations and clinical features, and their relationships. The medical records of...
Marianne Thomas-Pfaab et al.
Journal of dermatological science, 69(2), 105-113 (2012-12-12)
No biological or molecular marker of primary melanoma tumor cells has been shown to predict clinical outcome in melanoma. To determine whether CD10, CD133, nestin and CD20 may evaluate the prognosis of melanoma. The differential expression of these molecules was...
M D Miller et al.
Critical reviews in immunology, 12(1-2), 17-46 (1992-01-01)
Studies conducted in many laboratories over the past several years have resulted in the identification and initial characterization of a large superfamily of structurally and functionally related inflammatory cytokines. This superfamily currently includes 14 distinct members: platelet factor 4, beta-thromboglobulin...
Reena Sachdev et al.
American journal of clinical pathology, 133(6), 915-921 (2010-05-18)
CD163, a hemoglobin scavenger receptor, is expressed in monocytes and macrophages. Recent work has shown that this marker is specific for neoplasms of histiocytic differentiation. Our aim was to test the ability of CD163 to separate cutaneous histiocytomas from their...
Abdullah Al Yousef et al.
Photodermatology, photoimmunology & photomedicine, 28(1), 53-55 (2012-01-04)
Photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) is an effective treatment for several conditions such as Bowen's disease, subsets of basal cell carcinomas and actinic keratosis. Surgical resection is the first-choice therapy for extramammary Paget's disease (EMPD), but extensive resection...

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