Showing 1-30 of 708 results for "75-24-1"
Chi Wai Cheung et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 70(1), 25-30 (2011-08-09)
This double-blind randomized crossover study compared the analgesic efficacy of pre- and postoperative administration of oral pregabalin 75 mg using a postsurgical dental pain model. Patients requiring third molar surgery in 2 separate stages under local anesthesia were recruited. They...
Pieter-Jan De Kam et al.
Platelets, 25(7), 480-487 (2013-11-12)
Laropiprant is an antagonist of the prostaglandin PGD2 receptor DP1. Laropiprant has a weak affinity for the thromboxane A2 receptor TP. Two double-blinded, randomized, placebo-controlled, crossover studies evaluated the effects of multiple-dose laropiprant at steady state on the antiplatelet effects...
S J Pilkington et al.
Biochemistry, 30(8), 2166-2175 (1991-02-26)
Bovine mitochondrial NADH-ubiquinone reductase (complex I), the first enzyme in the electron-transport chain, is a membrane-bound assembly of more than 30 different proteins, and the flavoprotein (FP) fraction, a water-soluble assembly of the 51-, 24-, and 10-kDa subunits, retains some...
Sarbjit S Saini et al.
The Journal of investigative dermatology, 135(1), 67-75 (2014-07-22)
ASTERIA I was a 40-week, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of subcutaneous omalizumab as add-on therapy for 24 weeks in patients with chronic idiopathic urticaria/spontaneous urticaria (CIU/CSU) who remained symptomatic despite H1 antihistamine treatment at...
Julie Lecomte et al.
Breast cancer research and treatment, 112(3), 437-451 (2008-01-22)
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear receptor that can be activated by natural ligands such as 15-deoxy-delta(12,14)-prostaglandin J2 (15d-PGJ(2)) as well as synthetic drugs such as thiazolidinediones. The treatment of human breast cancer cell lines with PPARgamma agonists...
Chang-Yin Lee et al.
Oncology reports, 37(1), 399-407 (2016-11-15)
Panax notoginseng (P. notoginseng) and its components are used as traditional Chinese medicine for cardiovascular disease, although studies concerning the anti-metastatic properties of these compounds are limited. The goal of this study was to investigate the effects of notoginsenoside R1 (NGR1), an important...
L Pucci et al.
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 20(5), 461-469 (2003-11-25)
The glycoprotein IIIa (beta3 integrin) is an integral part of two glicoprotein receptors of platelets and, respectively, endothelium and vascular smooth muscle cells. The gene encoding the GPIIIa, a receptor for fibrinogen, vWF and fibronectin, shows polymorphism (PlA1/PlA2); the PlA2...
Carl Morrison et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 15(12), 1279-1287 (2002-12-14)
The distinction of hepatocellular carcinoma (HCC) from metastatic adenocarcinoma (MA) and cholangiocarcinoma (CC) in some cases requires the use of immunohistochemistry. CD10 has recently been suggested as a useful stain for HCC. We directly compared CD10 with other immunohistochemical markers...
C A Mitchell et al.
The Journal of biological chemistry, 264(15), 8873-8877 (1989-05-25)
We have identified, isolated, and characterized a second inositol polyphosphate-5-phosphatase enzyme from the soluble fraction of human platelets. The enzyme hydrolyzes inositol 1,4,5-trisphosphate (Ins (1,4,5)P3) to inositol 1,4-bisphosphate (Ins(1,4)P2) with an apparent Km of 24 microM and a Vmax of...
K Reiss et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(16), 8630-8635 (1996-08-06)
Transgenic mice were generated in which the cDNA for the human insulin-like growth factor 1B (IGF-1B) was placed under the control of a rat alpha-myosin heavy chain promoter. In mice heterozygous for the transgene, IGF-1B mRNA was not detectable in...
Pierre Beauparlant et al.
Anti-cancer drugs, 20(5), 346-354 (2009-04-17)
GMX1778 was recently shown to function as a potent inhibitor of nicotinamide phosphoribosyl transferase. To translate the discovery of GMX1778 mechanism of action into optimal clinical use of its intravenously administered prodrug, GMX1777, the efficacy of GMX1777 was evaluated in...
Yo-Han Ju et al.
Biotechnology letters, 32(2), 299-304 (2009-10-27)
A recombinant L-fucose isomerase from Caldicellulosiruptor saccharolyticus was purified as a single 68 kDa band with an activity of 76 U mg(-1). The molecular mass of the native enzyme was 204 kDa as a trimer. The maximum activity for L-fucose...
Viviana Asselborn et al.
Ecotoxicology and environmental safety, 120, 334-341 (2015-06-24)
The effect of the organophosphorus insecticide chlorpyrifos on the growth, biovolume, and ultrastructure of the green microalga Ankistrodesmus gracilis was evaluated. Concentrations of 9.37, 18.75, 37.5, 75 and 150mgL(-1) of chlorpyrifos were assayed along with a control culture. At the...
Y-S Kim et al.
Acta anaesthesiologica Scandinavica, 59(6), 788-795 (2015-03-05)
Intravenous or volatile agents reduce respiratory function, which can result in respiratory complications in geriatric patients. We hypothesised that there would be no differences in lung function between anaesthesia established using either drug. Elderly patients were randomly assigned to receive...
Yongjun Wang et al.
The New England journal of medicine, 369(1), 11-19 (2013-06-28)
Stroke is common during the first few weeks after a transient ischemic attack (TIA) or minor ischemic stroke. Combination therapy with clopidogrel and aspirin may provide greater protection against subsequent stroke than aspirin alone. In a randomized, double-blind, placebo-controlled trial...
Hugo Hilton et al.
American journal of veterinary research, 72(5), 681-686 (2011-05-03)
To determine expression of cyclooxygenase (COX) genes 1 and 2 (also called prostaglandin-endoperoxide synthases 1 and 2) and stability of housekeeping gene expression during low-flow ischemia and reperfusion in the jejunum of horses. 5 healthy adult horses. Horses were anesthetized...
Daniel M Roesel et al.
AJR. American journal of roentgenology, 201(2), W262-W270 (2013-07-26)
The purpose of this article is to assess normal imaging findings and complications after laparoscopic greater curvature plication on luminal upper gastrointestinal studies and CT. This was a retrospective chart review of 24 adults who underwent laparoscopic greater curvature plication...
Tian-yu Zhong et al.
Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 29(8), 1517-1520 (2009-09-04)
To examine the synergistic effect of recombinant human high mobility group box 1 (HMGB1) protein and lipopolysaccharides (LPS) on the release of interleukin-8 (IL-8) and monocyte chemotactic protein 1 (MCP-1) in human umbilic vein endothelial cells (HUVECs), and explore the...
Sumie Kato et al.
The Journal of clinical endocrinology and metabolism, 90(2), 1181-1188 (2004-11-25)
Progesterone in hormonal preparations increases the incidence of breast cancer. Tissue factor (TF), the initiator of the extrinsic coagulation pathway, is associated with metastasis in a wide variety of cancers. We demonstrate herein that TF mRNA and protein are up-regulated...
Olivier Lortholary et al.
Lancet (London, England), 389(10069), 612-620 (2017-01-11)
Indolent systemic mastocytosis, including the subvariant of smouldering systemic mastocytosis, is a lifelong condition associated with reduced quality of life. Masitinib inhibits KIT and LYN kinases that are involved in indolent systemic mastocytosis pathogenesis. We aimed to assess safety and...
Ashley Cimino-Mathews et al.
Human pathology, 44(6), 959-965 (2012-12-25)
The transcription factor Sox10 mediates the differentiation of neural crest-derived cells, and Sox10 labeling by immunohistochemistry (IHC) is used clinically primarily to support the diagnosis of melanoma. Sox10 expression by IHC has been previously documented in benign breast myoepithelial cells...
I Mansour et al.
Human reproduction (Oxford, England), 9(8), 1546-1549 (1994-08-01)
The expression of the progesterone receptor in human peripheral blood lymphocytes was analysed, using an enzyme linked immunosorbent assay (Abbott PgR-EIA monoclonal), in order to evaluate its prognostic character in the context of spontaneous abortion. Cytosols were prepared from lymphocytes...
Erik Hilborn et al.
Oncotarget, 8(37), 62183-62194 (2017-10-06)
To investigate the influence of estrogen, androgen, microRNAs, and genes implicated in breast cancer on the expression of HSD17B1 and HSD17B2. Breast cancer cell lines ZR-75-1, MCF7, T47D, SK-BR-3, and the immortalized epithelial cell line MCF10A were used. Cells were...
Aysegul Mine Tuzuner Oncul et al.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 20(5), 470-476 (2011-07-16)
The aim of this study was to compare the postoperative analgesic effects of preoperative intravenous (i.v.) paracetamol, diclofenac sodium and lornoxicam (nonsteroidal anti-inflammatory drugs). Sixty patients with impacted third molar who underwent surgical removal were randomly allocated into three groups:...
Sayyed Mohammad Hadi Alavi et al.
Fish physiology and biochemistry, 38(6), 1655-1666 (2012-06-06)
Spermiation and changes in androgen (testosterone, T and 11-ketotestosterone, 11-KT) levels were studied in sterlet (Acipenser ruthenus) treated with GnRH agonist implants (DAla(6)-Pro(9)-LHRHa) at 25 and 75 μg kg(-1) b.w. and compared with those males treated with 4 mg kg(-1)...
A al-Dehneh et al.
Journal of animal science, 72(2), 415-420 (1994-02-01)
Sixteen Alpine wethers (average BW 35 +/- 2 kg) were used to evaluate the effect of continuous 48-h intravenous infusions of saline (CON), mimosine (MIM; 200 mg.kg.75.d-1), 2-hydroxy-3(1H)-pyridine (2,3-DHP; 200 mg.kg.75.d-1, or MIM+2,3-DHP (100 mg of MIM plus 100 mg...
Zhanyong Bing et al.
Applied immunohistochemistry & molecular morphology : AIMM, 16(4), 316-321 (2008-06-06)
The Wilms tumor 1 (WT-1) is a zinc finger transcription factor essential for the development of the kidneys and gonads. Alterations in the WT-1 gene were observed in several tumor types. Depending on the tumor types, WT-1 might function as...
Vishwas D Joshi et al.
Journal of immunology (Baltimore, Md. : 1950), 169(5), 2536-2544 (2002-08-24)
LPS enhanced antibacterial host defenses (ABHD) when given at low (75 micro g) doses (16 of 19 mice survived 3x LD(50) Escherichia coli vs 3 of 19 LPS-naive mice; p = 0.0001), but induced lethal inflammation at high (500 micro...
R Sokół et al.
Polish journal of veterinary sciences, 18(2), 371-377 (2015-07-15)
The aim of the present study was to determine the efficacy of ivermectin against Cyathostominae infections and to describe the drug's pharmacokinetic parameters during two seasonal deworming treatments in horses. The study was performed on warm-blooded mares aged 3-12 years...
Cao Jin et al.
Biomarker insights, 14, 1177271919864892-1177271919864892 (2019-08-07)
Death domain-associated protein 6 (DAXX) is involved in regulating apoptosis via subcellular localization. The presence of DAXX point mutations correlates well with loss of nuclear expression on immunohistochemistry (IHC). In this study, we sought to determine (1) whether DAXX expression...

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