52619

Supelco

Hexamethyldisilazane

for GC derivatization, LiChropur, ≥99.0% (GC)

Synonym(s):
HMDS
Linear Formula:
(CH3)3SiNHSi(CH3)3
CAS Number:
Molecular Weight:
161.39
Beilstein/REAXYS Number:
635752
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

grade

for GC derivatization

assay

≥99.0% (GC)

quality

LiChropur

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

application(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.407 (lit.)
n20/D 1.408

bp

125 °C (lit.)

SMILES string

C[Si](C)(C)N[Si](C)(C)C

InChI

1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3

InChI key

FFUAGWLWBBFQJT-UHFFFAOYSA-N

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General description

Hexamethyldisilazane (HMDS) is a commercially available, silylating agent, which is used as an alternative for the preparation of silyl ethers from hydroxyl compounds.

Application

Suitable for the derivatization of alcohols, Υ-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.
Hexamethyldisilazane is suitable for the derivatization of alcohols, U-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.

It may be used as a derivatizing reagent for the analysis of bioamines and their acidic metabolites, phenol, hydroquinone and catechol in urine samples, mixtures of free fatty acids and metal soaps in paint samples using gas chromatography/mass spectrometry (GC/MS).
Learn more in the Product Information

Features and Benefits

  • HMDS is inexpensive and has a relatively low boiling point (124-127 °C).        
  • It can be used without solvent but its silylating power can be increased by various (mostly acidic) catalysts.        
  • The only reaction byproduct, ammonia, can leave the reaction mixture as the reaction goes to completion.

Other Notes

Important silylating agent
Reagent for 2-hydroxypyrimidine, polytrimethylsilyloxy, trimethylsilyl and trimethylsilyl oximes.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN 1992 6.1(3) / PGII

WGK Germany

WGK 2

Flash Point(F)

52.5 °F - closed cup

Flash Point(C)

11.4 °C - closed cup

Comprehensive profiling analysis of bioamines and their acidic metabolites in human urine by gas chromatography/mass spectrometry combined with selective derivatization
Park H-N, et al.
Journal of Chromatography A, 1305, 234-243 (2013)
Oxide-based Systems at the Crossroads of Chemistry (2001)
J. Heberle et al.
Silylating Agents, 2nd ed. (1995)
Jacopo La Nasa et al.
Analytica chimica acta, 1001, 51-58 (2018-01-03)
In this paper we present a new analytical GC/MS method for the analysis of mixtures of free fatty acids and metal soaps in paint samples. This approach is based on the use of two different silylating agents: N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) and...
G Lhoëst et al.
Biomedical mass spectrometry, 3(1), 21-27 (1976-02-01)
The biological implications, the reaction possibilities and the structure of different derivatives of N-hydroxy-2-fluorenylacetamide have been described.
Articles
Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs
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