ABC226

Sigma-Aldrich

Anti-USP7S Antibody

from rabbit, purified by affinity chromatography

Synonym(s):
Ubiquitin carboxyl-terminal hydrolase 7, Deubiquitinating enzyme 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin thioesterase 7, Ubiquitin-specific-processing protease 7
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

species reactivity (predicted by homology)

mouse (based on 100% sequence homology), Xenopus (based on 100% sequence homology), rat (based on 100% sequence homology), porcine (based on 100% sequence homology)

application(s)

western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

Gene Information

human ... USP7(7874)

General description

The protein named Ubiquitin carboxyl-terminal hydrolase 7, or Deubiquitinating enzyme 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin thioesterase 7, or Ubiquitin-specific-processing protease 7 and encoded by the human gene USP7/HAUSP is a ubiquitin specific hydrolase that deubiquitinates several key transcription factors and thus modulates their activity. Among the important factors are FOXO4, p53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, and DAXX. Thus USP7S is involved in cell proliferation and gene expression regulation and the regulation of the stress response pathways. Interestingly recent research has linked USP7S with regulating transcription-coupled nucleotide excision repair (TC-NER) and the being important in the disease of UV-sensitive syndrome (UVSS) too. USP7S is widely expressed and up regulated in many cancers including prostate cancer.

Immunogen

Epitope: N-terminus
KLH-conjugated linear peptide corresponding to a region near the N-terminus of human USP7S.

Application

Anti-USP7S Antibody detects level of USP7S & has been published & validated for use in USP7S.
Western Blotting Analysis: A 1:5,000 dilution of this antibody detected USP7S in HeLa whole cell extract (Dr. Grigory Dianov, University of Oxford, United Kingdom.)
Research Sub Category
Apoptosis - Additional
Research Category
Apoptosis & Cancer

Quality

Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected USP7S in 10 µg in HeLa cell lysate.

Target description

~140 kDa observed

Physical form

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity Purfied

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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