tBuDavePhos Pd G3

1:1 THF adduct

t-BuDavePhos Palladacycle, t-BuDavePhos G3 Palladacycle
Linear Formula:
C35H45N2O3PPdS · C4H8O
Pricing and availability is not currently available.


powder or crystals


generation 3

reaction suitability

core: palladium
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst
reaction type: Cross Couplings

functional group


SMILES string


General description

tBuDavePhos Pd G3 is a third generation (G3) Buchwald precatalyst. It is air, moisture and thermally-stable and is highly soluble in a wide range of common organic solvents. It has a long life in solutions. tBuDavePhos Pd G3 is an excellent reagent for palladium catalyzed cross-coupling reactions. Some of its unique features include lower catalyst loadings, shorter reaction time, efficient formation of the active catalytic species and accurate control of ligand: palladium ratio.


tBuDavePhos Pd G3 has been used as a precatalyst for the Synthesis of Aryl Sulfonamides via Palladium-Catalyzed Chlorosulfonylation of Arylboronic Acids. It may also be used for a variety of C-C and C-N cross-coupling reactions.

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
J Robb DeBergh et al.
Journal of the American Chemical Society, 135(29), 10638-10641 (2013-07-11)
A palladium-catalyzed method for the preparation of sulfonamides is described. The process exhibits significant functional group tolerance and allows for the preparation of a number of arylsulfonyl chlorides and sulfonamides under mild conditions.
Nicholas C Bruno et al.
Chemical science, 4, 916-920 (2013-05-15)
A series of easily prepared, phosphine-ligated palladium precatalysts based on the 2-aminobiphenyl scaffold have been prepared. The role of the precatalyst-associated labile halide (or pseudohalide) in the formation and stability of the palladacycle has been examined. It was found that...

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